Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581393 | 0.84 | PDE10A (0.56) | PDE10AFEN1 | |
| SCHEMBL2489333 | 0.81 | PDE10A (0.67) | PDE10A | |
| SCHEMBL7904646 | 0.80 | NCOA1 (0.58) | PDE10AFEN1 | |
| SCHEMBL15674303 | 0.79 | CLK4 (0.55) | PDE10ACLK4ADRA2CFEN1 | |
| SCHEMBL2455636 | 0.77 | PDE10A (0.58) | PDE10AFEN1 | |
| SCHEMBL2456284 | 0.75 | PDE10A (0.56) | PDE10AFEN1 | |
| SCHEMBL14878663 | 0.73 | PDE10A (0.58) | PDE10AFEN1 | |
| SCHEMBL1307835 | 0.73 | MAP4K4 (0.47) | PDE10ACLK4 | |
| SCHEMBL2483421 | 0.73 | PDE10A (0.59) | PDE10A | |
| SCHEMBL580894 | 0.72 | PDE10A (0.46) | PDE10AFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364306-B1 | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors | AMGEN INC (US) | 2013-04-24 | — | — | EP | disclosed |