Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14880179 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2GPR183HDAC8HDAC1HDAC3 | |
| SCHEMBL1481645 | 0.83 | MIF (0.53) | SMN1; SMN2GPR183MEN1LMNAKMT2A | |
| SCHEMBL1481643 | 0.83 | MIF (0.53) | SMN1; SMN2GPR183MEN1LMNAKMT2A | |
| SCHEMBL3118702 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2GPR183MEN1LMNAKMT2A | |
| SCHEMBL3118698 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2GPR183MEN1LMNAKMT2A | |
| SCHEMBL17157713 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2GPR183MEN1LMNAKMT2A | |
| SCHEMBL17157715 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2GPR183MEN1LMNAKMT2A | |
| SCHEMBL2797778 | 0.81 | MEN1 (0.55) | SMN1; SMN2GPR183MEN1LMNAKMT2A | |
| SCHEMBL2797777 | 0.81 | MEN1 (0.55) | SMN1; SMN2GPR183MEN1LMNAKMT2A | |
| SCHEMBL1645697 | 0.78 | BACE1 (0.69) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013059582-A2 | SMALL MOLECULE INHIBITORS OF HISTONE DEACTEYLASES | NUPOTENTIAL, INC. (US) | 2013-04-25 | — | — | WO | disclosed |