Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27008159 | 0.92 | HPGD (0.46) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL15227944 | 0.92 | HPGD (0.46) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL26978402 | 0.92 | HPGD (0.46) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL15227941 | 0.92 | HPGD (0.46) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL26978427 | 0.92 | HPGD (0.46) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL27008212 | 0.92 | HPGD (0.46) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL29099052 | 0.92 | HPGD (0.46) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL15227465 | 0.86 | NR1H2 (0.49) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL15716049 | 0.86 | NR1H2 (0.49) | HPGDRECQLNR1H2MEN1ALDH1A1 | |
| SCHEMBL1991642 | 0.86 | NR1H2 (0.49) | HPGDRECQLNR1H2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181564-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | HOFFMANN LA ROCHE (CH) | 2019-09-18 | — | — | EP | disclosed |
| EP-2922851-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH INC (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2013062835-A1 | SUBSTITUTED PIPERIDINYL COMPOUNDS USEFUL AS GPR119 AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2013062835-A1 | SUBSTITUTED PIPERIDINYL COMPOUNDS USEFUL AS GPR119 AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |