Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 1.00 |
| ▸ | HRH4 | Q9H3N8 | 17/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 9/20 | 1.00 |
| ▸ | HRH1 | P35367 | 4/20 | 1.00 |
| ▸ | HRH2 | P25021 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14895497 | 0.91 | HRH4 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895496 | 0.91 | HRH4 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14907406 | 0.82 | HRH3 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895141 | 0.81 | HRH3 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895371 | 0.81 | HRH4 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895133 | 0.81 | HRH3 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895435 | 0.79 | HRH4 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895221 | 0.79 | HRH4 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL16843185 | 0.78 | HRH4 (0.76) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895429 | 0.78 | HRH3 (0.64) | HRH3HRH4KCNH2HRH1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013060881-A1 | PYRIDOPYRIMIDINES AND THEIR THERAPEUTIC USE | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2013-05-02 | — | — | WO | claimed |
| EP-3378476-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2018-09-26 | — | — | EP | disclosed |
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| WO-2013060881-A1 | PYRIDOPYRIMIDINES AND THEIR THERAPEUTIC USE | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2013-05-02 | — | — | WO | disclosed |