SCHEMBL14899080

SCHEMBL14899080

C[C@H](N)C(=O)N1C2C[C@H]2C[C@H]1C#N

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 18/20 0.78
CYP3A4 P08684 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26690033 1.00 DPP4 (0.78) DPP4CYP3A4
SCHEMBL14216710 0.88 DPP4 (1.00) DPP4CYP3A4
SCHEMBL26688738 0.88 DPP4 (1.00) DPP4CYP3A4
SCHEMBL12063963 0.87 DPP4 (0.72) DPP4CYP3A4
SCHEMBL12937376 0.83 DPP4 (1.00) DPP4CYP3A4
SCHEMBL297630 0.83 DPP4 (1.00) DPP4CYP3A4
SCHEMBL14899582 0.83 DPP4 (0.75) DPP4
SCHEMBL15492500 0.82 DPP4 (0.82) DPP4CYP3A4
SCHEMBL14899002 0.82 DPP4 (0.82) DPP4CYP3A4
SCHEMBL13552341 0.81 DPP4 (0.65) DPP4CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE44186-E1 Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method BRISTOL-MYERS SQUIBB COMPANY (US) 2013-04-30 US disclosed