Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.55 |
| ▸ | JAK3 | P52333 | 16/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 16/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899198 | 0.87 | JAK2 (0.60) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL14899196 | 0.87 | JAK2 (0.71) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL14899229 | 0.86 | JAK2 (0.59) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL14899208 | 0.86 | JAK2 (0.55) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL13032382 | 0.85 | JAK2 (0.77) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL14899215 | 0.85 | JAK2 (0.56) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL14899200 | 0.84 | JAK2 (0.55) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL14899205 | 0.84 | JAK2 (0.55) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL14899214 | 0.84 | JAK2 (0.57) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL14899207 | 0.83 | JAK2 (0.56) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431596-B2 | [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds and their use | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2013-04-30 | — | — | US | disclosed |