Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 9/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16126910 | 0.94 | FGFR3 (0.51) | FGFR3KDRPIK3CAMAPK1MAPK8 | |
| SCHEMBL14901118 | 0.78 | MAPK1 (0.53) | FGFR3KDRPIK3CAMAPK1MAPK8 | |
| SCHEMBL14901221 | 0.77 | MAPK1 (0.53) | FGFR3KDRPIK3CAMAPK1MAPK8 | |
| SCHEMBL14901143 | 0.75 | MAPK1 (0.51) | FGFR3KDRPIK3CAMAPK1MAPK8 | |
| SCHEMBL14901213 | 0.74 | PIK3CA (0.53) | FGFR3KDRPIK3CAMAPK1MAPK8 | |
| SCHEMBL16133814 | 0.70 | FGFR3 (0.54) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL5759671 | 0.70 | PDGFRB (0.55) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL14901222 | 0.69 | FGFR3 (0.55) | FGFR3KDRPIK3CAMAPK1MAPK8 | |
| SCHEMBL14901126 | 0.69 | FGFR3 (0.40) | FGFR3KDRPIK3CAMAPK1MAPK8 | |
| SCHEMBL17035955 | 0.69 | FGFR3 (0.77) | FGFR3KDRFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013061080-A1 | ANTICANCER PYRIDOPYRAZINES VIA THE INHIBITION OF FGFR KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2013-05-02 | — | — | WO | disclosed |