Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 19/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 19/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1489532 | 0.91 | ADORA2A (0.61) | ADORA2AADORA1KCNH2 | |
| SCHEMBL1489303 | 0.90 | ADORA2A (0.73) | ADORA2AADORA1KCNH2 | |
| SCHEMBL1489765 | 0.90 | ADORA2A (0.63) | ADORA2AADORA1KCNH2 | |
| SCHEMBL1489538 | 0.89 | ADORA2A (0.63) | ADORA2AADORA1KCNH2 | |
| SCHEMBL1489531 | 0.87 | ADORA2A (0.56) | ADORA2AADORA1KCNH2 | |
| SCHEMBL1489731 | 0.85 | ADORA2A (0.57) | ADORA2AADORA1KCNH2 | |
| SCHEMBL1489343 | 0.84 | ADORA2A (0.57) | ADORA2AADORA1KCNH2 | |
| SCHEMBL1489438 | 0.83 | ADORA2A (0.55) | ADORA2AADORA1KCNH2 | |
| SCHEMBL1489768 | 0.83 | ADORA2A (0.55) | ADORA2AADORA1KCNH2 | |
| SCHEMBL4962442 | 0.80 | ADORA2A (0.55) | ADORA2AADORA1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888565-B1 | 2, 6-DI (HETERO) ARYL -4-AMIDO-PYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS | ALMIRALL SA (ES) | 2011-03-23 | — | — | EP | claimed |