Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905709 | 0.92 | RCE1 (0.45) | RCE1CSNK2A1CSNK2A2CSNK2BPDE7A | |
| SCHEMBL717365 | 0.87 | GCG (0.48) | — | |
| SCHEMBL716694 | 0.86 | NAMPT (0.35) | RCE1PDE7ALCKJAK3NAMPT | |
| SCHEMBL720764 | 0.86 | RCE1 (0.46) | RCE1PDE7AMERTKPOLBKDM4E | |
| SCHEMBL718249 | 0.85 | RCE1 (0.44) | RCE1PDE7AMERTKKDM4E | |
| SCHEMBL720081 | 0.82 | MEN1 (0.41) | PDE7A | |
| SCHEMBL719154 | 0.81 | GCG (0.43) | — | |
| SCHEMBL719453 | 0.81 | RCE1 (0.60) | RCE1PDE7ALCKJAK3MERTK | |
| SCHEMBL718563 | 0.81 | NAMPT (0.34) | RCE1PDE7ALCKJAK3NAMPT | |
| SCHEMBL14905663 | 0.80 | RCE1 (0.54) | RCE1PDE7ALCKJAK3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436043-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-07 | — | — | US | disclosed |