Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | TDO2 | P48775 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.34 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905730 | 0.90 | PDE2A (0.48) | PDE2ACSNK1DCHRNA7IDO1TDO2 | |
| SCHEMBL14905661 | 0.84 | CSNK1D (0.36) | PDE2ACSNK1DCHRNA7HTR3AEPHX1 | |
| SCHEMBL14905728 | 0.78 | RCE1 (0.43) | CSNK1DCHRNA7HTR3AEPHX2 | |
| SCHEMBL718693 | 0.77 | HSD17B2 (0.46) | ACHELMNAEPHX2GAA | |
| SCHEMBL14905704 | 0.74 | CSNK1D (0.38) | PDE2ACSNK1DCHRNA7EPHX1MEN1 | |
| SCHEMBL719872 | 0.73 | PDE2A (0.42) | PDE2ACSNK1DIDO1TDO2EPHX1 | |
| SCHEMBL719867 | 0.72 | GCG (0.54) | — | |
| SCHEMBL22277152 | 0.72 | EPHX2 (0.39) | PDE2ACHRNA7HTR3AEPHX2 | |
| SCHEMBL723030 | 0.71 | PDE2A (0.42) | PDE2ACSNK1DCHRNA7IDO1TDO2 | |
| SCHEMBL26081058 | 0.70 | DHODH (0.50) | PDE2AIDO1TDO2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436043-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-07 | — | — | US | disclosed |