Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 19/20 | 0.74 |
| ▸ | GSK3B | P49841 | 12/20 | 0.74 |
| ▸ | PRKACA | P17612 | 13/20 | 0.69 |
| ▸ | HIPK2 | Q9H2X6 | 13/20 | 0.69 |
| ▸ | PIM1 | P11309 | 12/20 | 0.69 |
| ▸ | CDK2 | P24941 | 12/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.69 |
| ▸ | MELK | Q14680 | 9/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 9/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 8/20 | 0.69 |
| ▸ | PAK4 | O96013 | 8/20 | 0.69 |
| ▸ | PRKX | P51817 | 8/20 | 0.69 |
| ▸ | CDK9 | P50750 | 8/20 | 0.69 |
| ▸ | STK17A | Q9UEE5 | 8/20 | 0.69 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.69 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.69 |
| ▸ | STK3 | Q13188 | 7/20 | 0.69 |
| ▸ | MINK1 | Q8N4C8 | 7/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1042723 | 1.00 | CDC7 (0.74) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL1047055 | 1.00 | CDC7 (0.74) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL1047057 | 1.00 | CDC7 (0.74) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL14905733 | 1.00 | CDC7 (0.74) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL1043681 | 0.88 | CDC7 (0.74) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL1041079 | 0.86 | CDC7 (0.72) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL1043587 | 0.85 | CDC7 (1.00) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL1045977 | 0.85 | CDC7 (0.71) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL1045976 | 0.85 | CDC7 (0.71) | CDC7GSK3BPRKACAHIPK2PIM1 | |
| SCHEMBL1045974 | 0.85 | CDC7 (0.71) | CDC7GSK3BPRKACAHIPK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435980-B2 | Pyrrolopyridine inhibitors of kinases | ABBVIE INC. (US) | 2013-05-07 | — | — | US | disclosed |