Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 9/20 | 0.56 |
| ▸ | PRKACA | P17612 | 7/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.56 |
| ▸ | GSK3B | P49841 | 6/20 | 0.56 |
| ▸ | CLK2 | P49760 | 6/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 6/20 | 0.56 |
| ▸ | PRKX | P51817 | 6/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 6/20 | 0.56 |
| ▸ | MINK1 | Q8N4C8 | 6/20 | 0.56 |
| ▸ | HIPK2 | Q9H2X6 | 6/20 | 0.56 |
| ▸ | MAP4K5 | Q9Y4K4 | 6/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | CDK9 | P50750 | 5/20 | 0.56 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.56 |
| ▸ | PAK4 | O96013 | 5/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1043726 | 0.89 | CDC7 (0.53) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL1049881 | 0.89 | CDC7 (0.46) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL14905755 | 0.86 | CDC7 (0.75) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL935975 | 0.83 | CDC7 (0.60) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL1048482 | 0.83 | CDC7 (0.49) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL1048481 | 0.83 | CDC7 (0.49) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL1045567 | 0.82 | CDC7 (0.48) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL1049062 | 0.82 | CDC7 (0.53) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL1050185 | 0.82 | CDC7 (0.53) | CDC7PRKACADYRK1AGSK3BCLK2 | |
| SCHEMBL1046429 | 0.81 | CDC7 (0.67) | CDC7PRKACADYRK1AGSK3BCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-B1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBVIE INC (US) | 2013-08-21 | — | — | EP | claimed |
| US-8435980-B2 | Pyrrolopyridine inhibitors of kinases | ABBVIE INC. (US) | 2013-05-07 | — | — | US | claimed |
| EP-2454257-B1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBVIE INC (US) | 2013-08-21 | — | — | EP | disclosed |
| US-8435980-B2 | Pyrrolopyridine inhibitors of kinases | ABBVIE INC. (US) | 2013-05-07 | — | — | US | disclosed |