Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 19/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 19/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906201 | 0.87 | PIM1 (0.63) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL14906153 | 0.87 | PIM1 (0.63) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL14892772 | 0.86 | CYP3A4 (0.58) | PIM1PIM3PIM2CYP3A4CYP2D6 | |
| SCHEMBL14892318 | 0.86 | CYP3A4 (0.58) | PIM1PIM3PIM2CYP3A4CYP2D6 | |
| SCHEMBL14906131 | 0.83 | PIM3 (0.63) | PIM1PIM3PIM2 | |
| SCHEMBL1911217 | 0.81 | CYP3A4 (0.61) | PIM1PIM3PIM2GSK3BCYP3A4 | |
| SCHEMBL14906171 | 0.81 | CYP3A4 (0.61) | PIM1PIM3PIM2GSK3BCYP3A4 | |
| SCHEMBL14892799 | 0.81 | PIM1 (0.61) | PIM1PIM3PIM2 | |
| SCHEMBL14905641 | 0.81 | PIM1 (0.58) | PIM1PIM3PIM2GSK3BPRKCQ | |
| SCHEMBL1911215 | 0.81 | PIM1 (0.58) | PIM1PIM3PIM2GSK3BPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109682-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109682-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | PIM1, GSK3A, GSK3B | PIM1 1/4885PIM3 5/4885PIM2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.