Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.54 |
| ▸ | PRKCA | P17252 | 3/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.54 |
| ▸ | ATR | Q13535 | 13/20 | 0.49 |
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906100 | 1.00 | GSK3B (0.54) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL14906093 | 0.92 | GSK3B (0.52) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL14906147 | 0.92 | GSK3B (0.52) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL14906126 | 0.91 | GSK3B (0.53) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL1911292 | 0.91 | GSK3B (0.53) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL14906167 | 0.90 | PIM2 (0.52) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL14906113 | 0.90 | PIM2 (0.52) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL14906213 | 0.90 | GSK3B (0.54) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL14892678 | 0.90 | GSK3B (0.54) | GSK3BPIM2DYRK1APRKCAPRKCQ | |
| SCHEMBL14892117 | 0.90 | GSK3B (0.54) | GSK3BPIM2DYRK1APRKCAPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109682-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109682-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | PIM1, GSK3A, GSK3B | GSK3B 3/4885PIM2 4/4885DYRK1A 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.