Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | DDO | Q99489 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18339403 | 0.88 | IKBKB (0.46) | FFAR1MAPTCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL834425 | 0.84 | MAPT (0.58) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL26680780 | 0.84 | CA12 (0.47) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL16782152 | 0.83 | ATM (0.47) | ALDH1A1FFAR1MAPTNPC1RAB9A | |
| SCHEMBL27701522 | 0.81 | FFAR1 (0.52) | LMNAFFAR1MAPTNPC1RAB9A | |
| SCHEMBL16782072 | 0.80 | KDR (0.64) | PDGFRBKDR | |
| SCHEMBL16782074 | 0.79 | KDR (0.44) | FFAR1MAPTPDGFRBKDR | |
| SCHEMBL1028239 | 0.79 | MAPT (0.45) | ALDH1A1FFAR1MAPTCSNK2A2CSNK2B | |
| SCHEMBL11949569 | 0.77 | MAPT (0.55) | MAPTPDGFRBKDRIKBKB | |
| SCHEMBL23012143 | 0.76 | HCAR2 (0.53) | KDM4EMEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768809-B1 | PYRIDINE-SULFOXIMINES AS TYROSINE KINASE INHIBITORS | ALLERGAN INC (US) | 2016-03-09 | — | — | EP | disclosed |
| WO-2015089220-A1 | SUBSTITUTED NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015089210-A1 | SUBSTITUTED DIALKYL(OXIDO)-Λ4-SULFANYLIDENE NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2013062843-A1 | PYRIDINE- SULFOXIMINES AS TYROSINE KINASE INHIBITORS | ALLERGAN, INC. (US) | 2013-05-02 | — | — | WO | disclosed |