Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.81 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.78 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.78 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.78 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874173 | 0.88 | KDM4E (0.77) | KDM4EHSD17B10MAPK1AKR1C4AKR1C3 | |
| SCHEMBL2624524 | 0.86 | AKR1C2 (0.75) | KDM4EHSD17B10MAPK1AKR1C4AKR1C3 | |
| SCHEMBL2270146 | 0.84 | CHEK1 (0.67) | KDM4EHSD17B10MAPK1AKR1C4AKR1C3 | |
| SCHEMBL11573780 | 0.84 | AKR1C4 (0.64) | KDM4EHSD17B10MAPK1AKR1C4AKR1C3 | |
| SCHEMBL2624528 | 0.82 | AKR1C2 (0.69) | KDM4EHSD17B10MAPK1AKR1C4AKR1C3 | |
| SCHEMBL28254139 | 0.82 | AKR1C4 (0.69) | KDM4EHSD17B10MAPK1AKR1C4AKR1C3 | |
| SCHEMBL1056451 | 0.82 | KMT2A (1.00) | KDM4EHSD17B10MAPK1KMT2AMEN1 | |
| SCHEMBL2935687 | 0.81 | MEN1 (0.69) | KDM4EHSD17B10MAPK1AKR1C3AKR1C2 | |
| SCHEMBL13788777 | 0.80 | MEN1 (0.78) | KDM4EHSD17B10MAPK1KMT2AMEN1 | |
| SCHEMBL2273065 | 0.80 | MAPK1 (0.57) | KDM4EHSD17B10MAPK1AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873661-B2 | Small molecule malarial Aldolase-TRAP enhancers and glideosome inhibitors | NEW YORK UNIVERSITY (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873661-B2 | Small molecule malarial Aldolase-TRAP enhancers and glideosome inhibitors | NEW YORK UNIVERSITY (US) | 2018-01-23 | — | — | US | disclosed |
| US-20140275088-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | THE JOHNS HOPKINS UNIVERSITY | 2014-09-18 | — | — | US | disclosed |
| US-20140275088-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | THE JOHNS HOPKINS UNIVERSITY | 2014-09-18 | — | — | US | disclosed |
| WO-2013063243-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | NEW YORK UNIVERSITY (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275088-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | ALDOA, DERA, TALDO1 | KDM4E 283/4885HSD17B10 2412/4885MAPK1 3475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.