Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16171075 | 0.91 | GRK6 (0.46) | GRK6ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL14907962 | 0.86 | GRK6 (0.67) | GRK6ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL14907809 | 0.83 | GRK6 (0.48) | GRK6ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16171076 | 0.83 | GRK6 (0.55) | GRK6ALDH1A1MEN1KMT2A | |
| SCHEMBL14907829 | 0.82 | GRK6 (0.64) | GRK6ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL17213086 | 0.82 | GRK6 (0.54) | GRK6ALDH1A1MEN1KMT2A | |
| SCHEMBL14907896 | 0.81 | GRK6 (0.43) | GRK6ALDH1A1MAPTGAA | |
| SCHEMBL21763940 | 0.81 | GRK6 (0.40) | GRK6ALDH1A1MAPT | |
| SCHEMBL14907807 | 0.81 | GRK6 (0.49) | GRK6ALDH1A1 | |
| SCHEMBL16171102 | 0.80 | GRK6 (0.56) | GRK6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015164415-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-10-29 | — | — | WO | disclosed |
| WO-2013063458-A2 | INHIBITING G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-05-02 | — | — | WO | disclosed |