Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 9/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411579 | 1.00 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| SCHEMBL2263363 | 1.00 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| Hydrochloric Acid SCHEMBL1411806 | 0.99 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| Bromide SCHEMBL1411406 | 0.99 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| Oxalic Acid SCHEMBL1411341 | 0.96 | PDE4A (0.43) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| Cadaverine Tartrate SCHEMBL1410696 | 0.93 | PDE4A (0.42) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| Alpha-Ketoglutaric Acid SCHEMBL1411393 | 0.90 | PDE4A (0.40) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| SCHEMBL1411112 | 0.89 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| SCHEMBL2265923 | 0.88 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CFPR2 | |
| SCHEMBL1411343 | 0.87 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2589599-B1 | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors | TAKEDA GMBH (DE) | 2014-06-25 | — | — | EP | disclosed |
| EP-2589599-A1 | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors | Takeda GmbH (DE) | 2013-05-08 | — | — | EP | disclosed |