Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 6/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411657 | 1.00 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| SCHEMBL14910606 | 1.00 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| Bromide SCHEMBL1411322 | 0.99 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| Hydrochloric Acid SCHEMBL1411662 | 0.99 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| Oxalic Acid SCHEMBL1411080 | 0.96 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| Sulfuric Acid SCHEMBL1411463 | 0.96 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| Fumaric Acid SCHEMBL1411479 | 0.93 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| Fumaric Acid SCHEMBL1411483 | 0.93 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| Cadaverine Tartrate SCHEMBL1410804 | 0.93 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPIK3CA | |
| Cadaverine Tartrate SCHEMBL1410803 | 0.93 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2589599-A1 | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors | Takeda GmbH (DE) | 2013-05-08 | — | — | EP | disclosed |