Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of L-Mimosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | TYR | P14679 | 2/20 | 0.70 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | RECQL | P46063 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mimosine SCHEMBL1491561 | 1.00 | KDM4E (0.70) | KDM4ETYRDOHHTDP1RECQL | |
| Mimosine SCHEMBL41924 | 0.84 | TYR (1.00) | KDM4ETYRDOHHTDP1RECQL | |
| L-Mimosine SCHEMBL11895399 | 0.84 | TYR (1.00) | KDM4ETYRDOHHTDP1RECQL | |
| L-Mimosine SCHEMBL41925 | 0.84 | TYR (1.00) | KDM4ETYRDOHHTDP1RECQL | |
| Mimosine SCHEMBL9878748 | 0.83 | TYR (0.97) | KDM4ETYRDOHHTDP1RECQL | |
| Mimosine SCHEMBL1720107 | 0.83 | TYR (0.97) | KDM4ETYRDOHHTDP1RECQL | |
| L-Mimosine SCHEMBL1720110 | 0.83 | TYR (0.97) | KDM4ETYRDOHHTDP1RECQL | |
| L-Mimosine SCHEMBL2164631 | 0.81 | TYR (0.94) | KDM4ETYRDOHHTDP1RECQL | |
| Mimosine SCHEMBL2164625 | 0.81 | TYR (0.94) | KDM4ETYRDOHHTDP1RECQL | |
| SCHEMBL17941358 | 0.79 | KDM4E (0.53) | KDM4ETYRDOHHTDP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473192-A1 | DISPERSANT STABILIZATION OF INORGANIC NON-METALLIC PARTICLES | ETH Zurich (CH) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011026572-A1 | DISPERSANT STABILIZATION OF INORGANIC NON-METALLIC PARTICLES | ETH ZURICH (CH) | 2011-03-10 | — | — | WO | disclosed |