Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levodopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.64 |
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.82 |
| ▸ | RECQL | P46063 | 4/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.82 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.82 |
| ▸ | USP2 | O75604 | 3/20 | 0.82 |
| ▸ | LCK | P06239 | 2/20 | 0.82 |
| ▸ | EGFR | P00533 | 1/20 | 0.82 |
| ▸ | FYN | P06241 | 1/20 | 0.82 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.82 |
| ▸ | HTR2A | P28223 | 1/20 | 0.82 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.64 |
| ▸ | DRD2 | P14416 | 2/20 | 0.64 |
| ▸ | DRD1 | P21728 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levodopa SCHEMBL5494247 | 1.00 | SLC7A5 (0.82) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Levodopa SCHEMBL1491628 | 1.00 | SLC7A5 (0.82) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Levodopa SCHEMBL5494243 | 1.00 | SLC7A5 (0.82) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Levodopa SCHEMBL28992922 | 0.98 | SLC7A5 (0.79) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Levodopa SCHEMBL6369139 | 0.94 | SLC7A5 (0.73) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Levodopa SCHEMBL29260902 | 0.94 | SLC7A5 (0.73) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Phenylalanine SCHEMBL9603018 | 0.93 | SLC7A5 (0.70) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Tyrosine SCHEMBL28116186 | 0.93 | SLC7A5 (0.70) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Dl-Phenylalanine SCHEMBL20898388 | 0.93 | SLC7A5 (0.70) | SLC7A5KDM4ERECQLTDP1ALOX15 | |
| Levodopa SCHEMBL23849465 | 0.91 | KDM4E (0.68) | SLC7A5KDM4ERECQLTDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868071-B | Novel dopamine precursors | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 2024-03-26 | — | — | CN | claimed |
| CN-113308124-B | Bone glue modified asphalt and preparation method thereof | 山东交通学院 | 2022-04-26 | — | — | CN | claimed |
| CN-112795335-B | High-strength water-resistant cellulose-based adhesive and preparation method thereof | 江南大学 | 2022-03-18 | — | — | CN | claimed |
| CN-112795335-A | High-strength water-resistant cellulose-based adhesive and preparation method thereof | 江南大学 | 2021-05-14 | — | — | CN | claimed |
| CN-108126766-A | A kind of micro-fluidic chip surface hydrophilic method of modifying | 深圳市梅丽纳米孔科技有限公司 | 2018-06-08 | — | — | CN | claimed |
| CN-111868071-B | Novel dopamine precursors | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-115612009-B | Hydrogel tissue adhesive based on dicarboxy amino acid and preparation method thereof | 西安交通大学 | 2024-02-13 | — | — | CN | disclosed |
| CN-116903855-A | Forked acrylic ester modified mussel-like hydrogel and preparation method thereof | 江苏科技大学 | 2023-10-20 | — | — | CN | disclosed |
| CN-115612009-A | Hydrogel tissue adhesive based on dicarboxy amino acid and preparation method thereof | 西安交通大学 | 2023-01-17 | — | — | CN | disclosed |
| CN-111569158-B | Preparation method of bionic tissue engineering scaffold with photo-thermal responsiveness and controllable drug release | 南通大学 | 2022-05-03 | — | — | CN | disclosed |
| CN-112795335-B | High-strength water-resistant cellulose-based adhesive and preparation method thereof | 江南大学 | 2022-03-18 | — | — | CN | disclosed |
| CN-112795335-A | High-strength water-resistant cellulose-based adhesive and preparation method thereof | 江南大学 | 2021-05-14 | — | — | CN | disclosed |
| US-20060269982-A1 | Rapid peptidoglycan-based assay for detection of bacterial contamination of platelets | IMMUNETICS, INC. (US) | 2006-11-30 | — | — | US | disclosed |
| EP-1692299-A1 | RAPID PEPTIDOGLYCAN-BASED ASSAY FOR DETECTION OF BACTERIAL CONTAMINATION OF PLATELETS | Immunetics, Inc. (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005045065-A1 | RAPID PEPTIDOGLYCAN-BASED ASSAY FOR DETECTION OF BACTERIAL CONTAMINATION OF PLATELETS | IMMUNETICS, INC. (US) | 2005-05-19 | — | — | WO | disclosed |
| EP-0449948-B1 | GRAFTING GENETICALLY MODIFIED CELLS TO TREAT DISEASES OF THE CENTRAL NERVOUS SYSTEM | UNIV CALIFORNIA (US) | 1999-09-22 | — | — | EP | disclosed |
| US-5082670-A | Genetic engineering, parkinson*s disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-01-21 | — | — | US | disclosed |
| EP-0449948-A4 | GRAFTING GENETICALLY MODIFIED CELLS TO TREAT DISEASES OF THE CENTRAL NERVOUS SYSTEM | — | 1991-11-13 | — | — | EP | disclosed |
| EP-0449948-A1 | GRAFTING GENETICALLY MODIFIED CELLS TO TREAT DISEASES OF THE CENTRAL NERVOUS SYSTEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990006757-A1 | GRAFTING GENETICALLY MODIFIED CELLS TO TREAT DISEASES OF THE CENTRAL NERVOUS SYSTEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1990-06-28 | — | — | WO | disclosed |