Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15711985 | 1.00 | PLAU (0.50) | PLAUMAPTL3MBTL1HSD17B10KMT2A | |
| SCHEMBL14917230 | 1.00 | PLAU (0.50) | PLAUMAPTL3MBTL1HSD17B10KMT2A | |
| SCHEMBL1355117 | 0.83 | PLAU (0.47) | PLAUMAPTL3MBTL1HSD17B10KMT2A | |
| SCHEMBL1355119 | 0.83 | PLAU (0.47) | PLAUMAPTL3MBTL1HSD17B10KMT2A | |
| SCHEMBL16926828 | 0.80 | MAPT (0.40) | PLAUMAPTL3MBTL1HSD17B10KMT2A | |
| SCHEMBL22271023 | 0.77 | PLAU (0.50) | PLAUMAPTL3MBTL1HSD17B10KMT2A | |
| SCHEMBL31541891 | 0.74 | KMT2A (0.43) | MAPTL3MBTL1HSD17B10KMT2AMAPK1 | |
| SCHEMBL14927124 | 0.73 | PLAU (0.54) | PLAUMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14917059 | 0.73 | PLAU (0.54) | PLAUMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14917060 | 0.73 | PLAU (0.54) | PLAUMAPK1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773640-B1 | BICYCLIC PIPERAZINE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| EP-2773640-A1 | BICYCLIC PIPERAZINE COMPOUNDS | Hoffmann-La Roche AG (CH) | 2014-09-10 | — | — | EP | disclosed |
| US-8722676-B2 | Bicyclic piperazine compounds | GENENTECH, INC. (US) | 2014-05-13 | — | — | US | disclosed |
| WO-2013067260-A1 | BICYCLIC PIPERAZINE COMPOUNDS | GENENTECH, INC. (US) | 2013-05-10 | — | — | WO | disclosed |
| US-20130116262-A1 | BICYCLIC PIPERAZINE COMPOUNDS | GENENTECH, INC. (US) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116262-A1 | BICYCLIC PIPERAZINE COMPOUNDS | BTK, LCK, SYK | PLAU 3841/4885MAPT 1911/4885L3MBTL1 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.