Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.52 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | STK32B | Q9NY57 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917447 | 0.79 | HSP90AA1 (0.46) | PIM1BMPR1BPIK3C2GCDKL5TYK2 | |
| SCHEMBL30108283 | 0.78 | PARP1 (0.50) | PIM1BMPR1BPIK3C2GCDKL5TYK2 | |
| SCHEMBL31032045 | 0.78 | PARP1 (0.50) | PIM1BMPR1BPIK3C2GCDKL5TYK2 | |
| SCHEMBL4936429 | 0.78 | PARP1 (0.50) | PIM1BMPR1BPIK3C2GCDKL5TYK2 | |
| SCHEMBL14917460 | 0.78 | MEN1 (0.47) | PIM1CLK4SRCIKBKB | |
| SCHEMBL944311 | 0.75 | PDGFRB (0.58) | PIM1BMPR1BPIK3C2GCDKL5TYK2 | |
| SCHEMBL17610492 | 0.75 | IKBKB (0.49) | PIM1BMPR1BPIK3C2GCDKL5TYK2 | |
| SCHEMBL17610510 | 0.75 | PIM1 (0.53) | PIM1BMPR1BPIK3C2GCDKL5TYK2 | |
| SCHEMBL14917433 | 0.73 | MKNK1 (0.50) | PIM1HSP90AA1MKNK2CYP2A6IKBKB | |
| SCHEMBL16246953 | 0.73 | RIPK2 (0.71) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193611-B1 | MK2 INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2021-03-24 | — | — | EP | disclosed |
| EP-3193611-A2 | MK2 INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044463-A2 | MK2 INHIBITORS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | PIM1 1831/4885BMPR1B 4018/4885PIK3C2G 1664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.