Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 16/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29877691 | 1.00 | HDAC6 (0.71) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL23711190 | 0.94 | HDAC6 (0.65) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL2567937 | 0.84 | HDAC6 (0.54) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL19745638 | 0.84 | HDAC1 (1.00) | HDAC6HDAC1HDAC5HDAC8 | |
| SCHEMBL14993379 | 0.83 | HDAC6 (0.56) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL14918176 | 0.82 | HDAC6 (0.55) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL20335377 | 0.81 | HDAC6 (0.54) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL19745599 | 0.81 | HDAC6 (0.54) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL31259010 | 0.81 | HDAC6 (0.70) | HDAC6HDAC1HDAC5HDAC8HDAC4 | |
| SCHEMBL18796020 | 0.81 | HDAC6 (0.70) | HDAC6HDAC1HDAC5HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066831-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013066831-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |