Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918271 | 0.89 | HDAC6 (0.61) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL14918189 | 0.89 | HDAC6 (0.53) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL17394571 | 0.86 | HDAC6 (0.64) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL14918277 | 0.84 | HDAC6 (0.66) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL14917787 | 0.82 | HDAC6 (0.69) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL14918062 | 0.82 | HDAC6 (0.69) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL14918119 | 0.80 | HDAC1 (0.66) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL14918150 | 0.79 | HDAC6 (0.69) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL14918305 | 0.79 | HDAC6 (0.69) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL213325 | 0.78 | HDAC1 (0.71) | HDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |