Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918077 | 0.91 | HDAC6 (0.58) | HDAC1HDAC6HDAC8ZAP70HDAC4 | |
| SCHEMBL14918323 | 0.91 | HDAC8 (0.55) | HDAC1HDAC6HDAC8 | |
| SCHEMBL14918033 | 0.91 | HDAC1 (0.49) | HDAC1HDAC6HDAC8ZAP70HDAC4 | |
| SCHEMBL14918679 | 0.85 | HDAC6 (0.56) | HDAC1HDAC6HDAC8HDAC4HDAC5 | |
| SCHEMBL14918011 | 0.85 | HDAC4 (0.55) | HDAC1HDAC6HDAC8HDAC4HDAC5 | |
| SCHEMBL14918140 | 0.83 | HDAC6 (0.50) | HDAC1HDAC6HDAC8HDAC4HDAC5 | |
| SCHEMBL14918664 | 0.82 | HDAC1 (0.57) | HDAC1HDAC6HDAC8ZAP70HDAC4 | |
| SCHEMBL14917948 | 0.81 | HDAC8 (0.55) | HDAC1HDAC6HDAC8 | |
| SCHEMBL14918257 | 0.79 | HDAC6 (0.50) | HDAC1HDAC6HDAC8HDAC4 | |
| SCHEMBL14918853 | 0.79 | HDAC6 (0.50) | HDAC1HDAC6HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |