Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918227 | 0.92 | HDAC6 (0.59) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14918680 | 0.90 | HDAC6 (0.58) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14918528 | 0.90 | HDAC4 (0.55) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14918763 | 0.84 | HDAC4 (0.55) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14918806 | 0.84 | HDAC4 (0.59) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14918251 | 0.84 | HDAC6 (0.59) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14918720 | 0.83 | HDAC4 (0.57) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14918826 | 0.83 | HDAC6 (0.59) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14917846 | 0.83 | HDAC4 (0.59) | HDAC6HDAC1HDAC8HDAC5HDAC4 | |
| SCHEMBL14918509 | 0.81 | HDAC6 (0.58) | HDAC6HDAC1HDAC8HDAC5HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066835-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |