Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 20/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 19/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918084 | 0.90 | HDAC6 (0.62) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14918586 | 0.90 | HDAC6 (0.50) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14918386 | 0.86 | HDAC8 (0.54) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14918191 | 0.84 | HDAC8 (0.59) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14918490 | 0.84 | HDAC6 (0.64) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14918293 | 0.83 | HDAC8 (0.64) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14918413 | 0.83 | HDAC8 (0.71) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14918583 | 0.83 | HDAC8 (0.57) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14918312 | 0.81 | HDAC8 (0.60) | HDAC8HDAC6HDAC1 | |
| SCHEMBL14917948 | 0.80 | HDAC8 (0.55) | HDAC8HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |