Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918075 | 0.90 | HDAC4 (0.63) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL14918803 | 0.90 | HDAC6 (0.52) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL21900007 | 0.89 | HDAC6 (0.62) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL14918121 | 0.88 | HDAC6 (0.54) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL14918621 | 0.87 | HDAC6 (0.53) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL14918385 | 0.86 | HDAC6 (0.57) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL14918284 | 0.86 | HDAC4 (0.55) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL14918683 | 0.85 | HDAC6 (0.52) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL14918270 | 0.84 | HDAC6 (0.50) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL14917874 | 0.84 | HDAC6 (0.50) | HDAC6HDAC4HDAC1HDAC5HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066835-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |