Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918276 | 0.89 | HDAC8 (0.58) | HDAC6HDAC1HDAC8 | |
| SCHEMBL14918668 | 0.87 | HDAC6 (0.66) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL14918060 | 0.84 | HDAC6 (0.52) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL14918682 | 0.82 | HDAC6 (0.56) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL14918649 | 0.80 | HDAC6 (0.54) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL14918722 | 0.80 | HDAC6 (0.57) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL14918853 | 0.79 | HDAC6 (0.50) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL14918257 | 0.79 | HDAC6 (0.50) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL14918586 | 0.78 | HDAC6 (0.50) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL14918033 | 0.77 | HDAC1 (0.49) | HDAC6HDAC1HDAC4HDAC8ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |