Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918679 | 0.91 | HDAC6 (0.56) | HDAC6HDAC4HDAC1HDAC8JAK2 | |
| SCHEMBL14918064 | 0.91 | HDAC6 (0.56) | HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL14918575 | 0.88 | HDAC1 (0.59) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL14918077 | 0.85 | HDAC6 (0.58) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL21407358 | 0.84 | HDAC6 (0.75) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL14918860 | 0.83 | HDAC1 (0.61) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL14917788 | 0.82 | HDAC1 (0.61) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14645546 | 0.79 | HDAC4 (1.00) | HDAC6HDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL14918846 | 0.78 | HDAC6 (0.66) | HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL14918150 | 0.78 | HDAC6 (0.69) | HDAC6HDAC4HDAC1HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066839-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |