SCHEMBL14918645

SCHEMBL14918645

O=C(NCCOc1ccc(-c2noc(C(F)(F)F)n2)cc1)N1CCN(Cc2ccccc2)CC1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 10/20 0.59
HDAC3 O15379 2/20 0.59
HDAC7 Q8WUI4 2/20 0.59
HDAC9 Q9UKV0 2/20 0.59
HDAC5 Q9UQL6 2/20 0.59
NCOR2 Q9Y618 2/20 0.59
HDAC6 Q9UBN7 6/20 0.53
PDE3B Q13370 2/20 0.52
PDE3A Q14432 2/20 0.52
STAT3 P40763 7/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
ALDH1A1 P00352 1/20 0.50
MAPT P10636 1/20 0.50
TSHR P16473 1/20 0.50
HTT P42858 1/20 0.50
HDAC1 Q13547 2/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC8 Q9BY41 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14918183 0.85 HDAC4 (0.62) HDAC4HDAC3HDAC7HDAC9HDAC5
SCHEMBL14917776 0.82 HDAC4 (0.63) HDAC4HDAC3HDAC7HDAC5HDAC6
SCHEMBL14917713 0.80 HDAC4 (0.71) HDAC4HDAC3HDAC7HDAC9HDAC5
SCHEMBL14917705 0.80 HDAC4 (0.65) HDAC4HDAC3HDAC7HDAC9HDAC5
SCHEMBL14917704 0.80 HDAC4 (0.65) HDAC4HDAC3HDAC7HDAC9HDAC5
SCHEMBL14917953 0.79 HDAC4 (0.49) HDAC4HDAC3HDAC7HDAC9HDAC5
SCHEMBL14918214 0.77 HDAC4 (0.60) HDAC4HDAC3HDAC7HDAC9HDAC5
SCHEMBL445115 0.77 HDAC1 (0.62) HDAC4HDAC3HDAC7HDAC9HDAC5
SCHEMBL14918705 0.76 SMN1; SMN2 (0.59) HDAC4HDAC5HDAC6ALDH1A1HDAC1
SCHEMBL14918703 0.76 SMN1; SMN2 (0.59) HDAC4HDAC5HDAC6ALDH1A1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013066833-A1 COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES GLAXOSMITHKLINE LLC (US) 2013-05-10 WO claimed
WO-2013066833-A1 COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed