SCHEMBL14918686

SCHEMBL14918686

O=C(C=Cc1ccccc1)NCCCOc1cc(-c2noc(C(F)(F)F)n2)on1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 2/20 0.46
HDAC4 P56524 6/20 0.45
HDAC6 Q9UBN7 5/20 0.45
ALDH1A1 P00352 1/20 0.42
EGFR P00533 1/20 0.41
HDAC1 Q13547 2/20 0.41
HDAC3 O15379 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
CYP1A2 P05177 1/20 0.39
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.39
DRD2 P14416 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14918685 1.00 SMN1; SMN2 (0.46) SMN1; SMN2RAB9AKMT2AHDAC4HDAC6
SCHEMBL14918377 0.97 SMN1; SMN2 (0.49) SMN1; SMN2RAB9AKMT2AHDAC4HDAC6
SCHEMBL14918376 0.97 SMN1; SMN2 (0.49) SMN1; SMN2RAB9AKMT2AHDAC4HDAC6
SCHEMBL14918703 0.81 SMN1; SMN2 (0.59) SMN1; SMN2RAB9AKMT2AHDAC4HDAC6
SCHEMBL14918705 0.81 SMN1; SMN2 (0.59) SMN1; SMN2RAB9AKMT2AHDAC4HDAC6
SCHEMBL14917779 0.80 HDAC4 (0.52) SMN1; SMN2RAB9AKMT2AHDAC4HDAC6
SCHEMBL14917778 0.80 HDAC4 (0.52) SMN1; SMN2RAB9AKMT2AHDAC4HDAC6
SCHEMBL14917762 0.80 HDAC6 (0.56) HDAC4HDAC6HDAC1HDAC3HDAC7
SCHEMBL14917814 0.78 HPGD (0.51) SMN1; SMN2RAB9AKMT2AHDAC4HDAC6
SCHEMBL14917703 0.78 HDAC4 (0.51) HDAC4HDAC6HDAC1HDAC3HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013066833-A1 COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES GLAXOSMITHKLINE LLC (US) 2013-05-10 WO claimed
WO-2013066833-A1 COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed