Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21996242 | 0.93 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL31732068 | 0.80 | HRH3 (0.33) | MAPK1 | |
| SCHEMBL11002456 | 0.79 | CTSC (0.34) | MAPK1 | |
| SCHEMBL30335568 | 0.78 | HRH3 (0.31) | MAPK1 | |
| SCHEMBL29172772 | 0.74 | — | — | |
| SCHEMBL25340995 | 0.73 | MAPK1 (0.34) | MAPK1 | |
| SCHEMBL16555248 | 0.73 | BACE1 (0.36) | — | |
| SCHEMBL29172798 | 0.73 | — | — | |
| SCHEMBL30749401 | 0.72 | BACE1 (0.41) | — | |
| Hydrochloric Acid SCHEMBL31743747 | 0.72 | MAPK1 (0.31) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773351-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013066718-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-05-10 | — | — | WO | disclosed |