Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513513 | 0.85 | SCN9A (0.55) | HTTKDM4EALPLSCN9A | |
| SCHEMBL4504237 | 0.82 | SCN9A (0.48) | HTTPOLBSMN1; SMN2KDM4EALPL | |
| SCHEMBL14921511 | 0.81 | SLC22A12 (0.53) | ALPL | |
| SCHEMBL4503426 | 0.81 | SCN9A (0.46) | SMN1; SMN2KDM4EALPLSCN9A | |
| SCHEMBL14921549 | 0.80 | PIK3C3 (0.50) | ALDH1A1LMNAKDM4EALPLSCN9A | |
| SCHEMBL29835236 | 0.77 | SCN1A (0.59) | SCN9A | |
| SCHEMBL29835168 | 0.77 | SCN1A (0.53) | KMT2AALDH1A1KDM4EALPLSCN9A | |
| SCHEMBL4500062 | 0.76 | SCN9A (0.52) | SCN9A | |
| SCHEMBL29835179 | 0.75 | SCN9A (0.57) | ALDH1A1LMNAKDM4EALPLSCN9A | |
| SCHEMBL14921116 | 0.75 | SCN9A (0.57) | ALDH1A1LMNAKDM4EALPLSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773641-A1 | BIARYL ETHER SULFONAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013064984-A1 | BIARYL ETHER SULFONAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2013-05-10 | — | — | WO | disclosed |