Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | STAT6 | P42226 | 5/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14908668 | 0.90 | SYK (0.49) | SYKBTKKCNH2STAT6KCNQ3 | |
| SCHEMBL14909002 | 0.87 | SYK (0.48) | SYKBTKKCNH2STAT6KCNQ3 | |
| SCHEMBL20473613 | 0.87 | SYK (0.48) | SYKBTKKCNH2STAT6KCNQ3 | |
| SCHEMBL14908945 | 0.85 | BTK (0.52) | SYKBTKKCNH2STAT6KCNQ3 | |
| SCHEMBL14909948 | 0.83 | SYK (0.54) | SYKBTKKCNH2STAT6KCNQ3 | |
| SCHEMBL14909950 | 0.83 | SYK (0.54) | SYKBTKKCNH2STAT6KCNQ3 | |
| SCHEMBL16165420 | 0.79 | SYK (0.49) | SYKSTAT6 | |
| SCHEMBL16165381 | 0.79 | BTK (0.47) | SYKBTKKCNH2STAT6KCNQ3 | |
| SCHEMBL16165382 | 0.79 | BTK (0.47) | SYKBTKKCNH2STAT6KCNQ3 | |
| SCHEMBL16164547 | 0.78 | SYK (0.50) | SYKSTAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2589592-A1 | NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF | FUJIFILM Corporation (JP) | 2013-05-08 | — | — | EP | disclosed |