Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.71 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.71 |
| ▸ | CAMK1D | Q8IU85 | 3/20 | 0.71 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.70 |
| ▸ | BTK | Q06187 | 1/20 | 0.70 |
| ▸ | ITK | Q08881 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14911307 | 0.89 | SYK (0.61) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14911001 | 0.89 | SYK (0.56) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14923798 | 0.86 | SYK (0.53) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL6156796 | 0.85 | SYK (0.71) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14923733 | 0.85 | SYK (0.52) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14923870 | 0.85 | SYK (0.69) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14929435 | 0.84 | SYK (0.56) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14910187 | 0.84 | SYK (0.57) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14910698 | 0.84 | SYK (0.54) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL29794661 | 0.83 | SYK (1.00) | SYKZAP70CAMK1DPRKCEBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-8772320-B2 | — | — | 2014-07-08 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
| EP-2589592-A1 | NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF | FUJIFILM Corporation (JP) | 2013-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | SYK 1/4885ZAP70 183/4885CAMK1D 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.