Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.55 |
| ▸ | JAK2 | O60674 | 6/20 | 0.54 |
| ▸ | JAK1 | P23458 | 6/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.54 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10076719 | 1.00 | SYK (0.57) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14923924 | 0.93 | SYK (0.55) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14928610 | 0.89 | FER (0.56) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14909992 | 0.89 | FER (0.56) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14909995 | 0.89 | FER (0.56) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL2717985 | 0.85 | SYK (0.70) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL10254891 | 0.85 | SYK (0.71) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL2715340 | 0.84 | SYK (0.73) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14910615 | 0.84 | FER (0.42) | SYKJAK2JAK1JAK3FER | |
| SCHEMBL14909509 | 0.82 | FER (0.42) | SYKJAK2JAK1FER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
| EP-2589592-A1 | NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF | FUJIFILM Corporation (JP) | 2013-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | SYK 1/4885MAPK3 559/4885MAPK1 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.