Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CDK9 | P50750 | 2/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 9/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CAMK1D | Q8IU85 | 5/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14908775 | 0.91 | CAMK1D (0.53) | CCNT1CCNE1CDK2CDK9NTRK1 | |
| SCHEMBL14908936 | 0.90 | CAMK1D (0.54) | NTRK1SYKZAP70KCNH2AURKB | |
| SCHEMBL14931162 | 0.89 | NTRK1 (0.46) | NTRK1SYKZAP70KCNH2AURKB | |
| SCHEMBL14923798 | 0.85 | SYK (0.53) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL14923748 | 0.84 | SYK (0.53) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL14908854 | 0.82 | SYK (0.51) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL14909355 | 0.81 | SYK (0.50) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL14923870 | 0.80 | SYK (0.69) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL14909563 | 0.79 | SYK (0.55) | SYKZAP70KCNH2AURKBCAMK1D | |
| SCHEMBL14911348 | 0.78 | SYK (0.53) | SYKZAP70KCNH2AURKBCAMK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2589592-B1 | NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF | FUJIFILM CORP (JP) | 2018-08-22 | — | — | EP | disclosed |
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
| EP-2589592-A1 | NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF | FUJIFILM Corporation (JP) | 2013-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | CCNT1 3095/4885CCNE1 4424/4885CDK2 2278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.