Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.71 |
| ▸ | HPGD | P15428 | 8/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.71 |
| ▸ | CASP1 | P29466 | 4/20 | 0.71 |
| ▸ | CASP7 | P55210 | 4/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | GLA | P06280 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7798964 | 0.93 | KDM4E (0.74) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL14925274 | 0.89 | KDM4E (0.60) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL14925290 | 0.88 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL14930177 | 0.87 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL14916213 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL2555949 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL30406107 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL2554744 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL14925310 | 0.82 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL20478129 | 0.82 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |
| US-9867803-B2 | IRE-1α inhibitors | SHANGHAI FOSUN PHARMACEUTICAL INDUSTRIAL DEVELOPMENT CO. LTD. (CN) | 2018-01-16 | — | — | US | disclosed |
| US-20170326104-A1 | IRE-1ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2017-11-16 | — | — | US | disclosed |
| US-9693992-B2 | IRE-1α inhibitors | MANNKIND CORPORATION (US) | 2017-07-04 | — | — | US | disclosed |
| US-9040714-B2 | IRE-1α inhibitors | MANNKIND CORPORATION (US) | 2015-05-26 | — | — | US | disclosed |
| US-20150141424-A1 | IRE-1alpha INHIBITORS | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2015-05-21 | — | — | US | disclosed |
| US-20130116247-A1 | IRE-1alpha INHIBITORS | MANNKIND CORPORATION (US) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141424-A1 | IRE-1alpha INHIBITORS | ERN1, XBP1, ERN2 | KDM4E 2950/4885ALDH1A1 2024/4885HPGD 649/4885 |
| US-20170326104-A1 | IRE-1ALPHA INHIBITORS | ERN1, XBP1, ERN2 | KDM4E 2950/4885ALDH1A1 2024/4885HPGD 649/4885 |
| US-20130116247-A1 | IRE-1alpha INHIBITORS | ERN1, XBP1, ERN2 | KDM4E 2975/4885ALDH1A1 2036/4885HPGD 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.