Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21451430 | 1.00 | NAALAD2 (0.36) | NAALAD2CD274PDCD1PDCD1LG2TSHR | |
| SCHEMBL21451342 | 1.00 | NAALAD2 (0.36) | NAALAD2CD274PDCD1PDCD1LG2TSHR | |
| SCHEMBL23052652 | 0.82 | — | — | |
| SCHEMBL24476511 | 0.81 | NAALAD2 (0.33) | NAALAD2CD274PDCD1PDCD1LG2 | |
| SCHEMBL24476311 | 0.81 | NAALAD2 (0.33) | NAALAD2CD274PDCD1PDCD1LG2 | |
| SCHEMBL20999124 | 0.79 | TSHR (0.39) | NAALAD2CD274PDCD1PDCD1LG2TSHR | |
| SCHEMBL22487748 | 0.79 | TSHR (0.39) | NAALAD2CD274PDCD1PDCD1LG2TSHR | |
| SCHEMBL10207220 | 0.79 | TSHR (0.39) | NAALAD2CD274PDCD1PDCD1LG2TSHR | |
| SCHEMBL24134793 | 0.77 | NAALAD2 (0.36) | NAALAD2CD274PDCD1PDCD1LG2TSHR | |
| SCHEMBL23052783 | 0.77 | TSHR (0.32) | TSHRALDH1A1CYP2D6CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11384048-B2 | Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2022-07-12 | — | — | US | disclosed |
| US-20220168268-A1 | SMALL-MOLECULE INHIBITOR OF PD-1/PD-L1, PHARMACEUTICAL COMPOSITION THEREOF WITH PD-L1 ANTIBODY, AND APPLICATION OF SAME | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2022-06-02 | — | — | US | disclosed |
| US-20210387941-A1 | Diphenyl-like Compound, Intermediate Thereof, Preparation Method Therefor, Pharmaceutical Composition Thereof And Uses Thereof | SHANGHAI MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2021-12-16 | — | — | US | disclosed |
| US-11078192-B2 | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. | 2021-08-03 | — | — | US | disclosed |
| US-20210061755-A1 | AROMATIC VINYL OR AROMATIC ETHYL DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2021-03-04 | — | — | US | disclosed |
| US-20190308957-A1 | AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD (CN) | 2019-10-10 | — | — | US | disclosed |
| US-9029405-B2 | 5-(biphenyl-4-yl)-3-phenyl-1,2,4-oxadiazolyl derivatives as ligands on the sphingosine 1-phosphate(SIP)receptors | MERCK SERONO S.A. (CH) | 2015-05-12 | — | — | US | disclosed |
| US-9029405-B2 | 5-(biphenyl-4-yl)-3-phenyl-1,2,4-oxadiazolyl derivatives as ligands on the sphingosine 1-phosphate(SIP)receptors | MERCK SERONO S.A. (CH) | 2015-05-12 | — | — | US | disclosed |
| US-20130116289-A1 | 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS | MERCK SERONO S.A. (CH) | 2013-05-09 | — | — | US | disclosed |
| US-20130116289-A1 | 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS | MERCK SERONO S.A. (CH) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116289-A1 | 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS | S1PR1, S1PR5, S1PR2 | NAALAD2 3585/4885CD274 649/4885PDCD1 1368/4885 |
| US-11384048-B2 | Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application | PDCD1, CD274, PDCD1LG2 | NAALAD2 3302/4885CD274 2/4885PDCD1 1/4885 |
| US-20210061755-A1 | AROMATIC VINYL OR AROMATIC ETHYL DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION | PDCD1, CD274, PDCD1LG2 | NAALAD2 3302/4885CD274 2/4885PDCD1 1/4885 |
| US-20220168268-A1 | SMALL-MOLECULE INHIBITOR OF PD-1/PD-L1, PHARMACEUTICAL COMPOSITION THEREOF WITH PD-L1 ANTIBODY, AND APPLICATION OF SAME | PDCD1, PDCD1LG2, CD274 | NAALAD2 2494/4885CD274 3/4885PDCD1 1/4885 |
| US-20210387941-A1 | Diphenyl-like Compound, Intermediate Thereof, Preparation Method Therefor, Pharmaceutical Composition Thereof And Uses Thereof | CD274, PDCD1LG2, PDCD1 | NAALAD2 2483/4885CD274 1/4885PDCD1 3/4885 |
| US-20190308957-A1 | AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | PDCD1, CD274, PDCD1LG2 | NAALAD2 839/4885CD274 2/4885PDCD1 1/4885 |
| US-11078192-B2 | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof | PDCD1, CD274, PDCD1LG2 | NAALAD2 839/4885CD274 2/4885PDCD1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.