Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 7/20 | 0.38 |
| ▸ | CA12 | O43570 | 6/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104448 | 0.86 | PTPRC (0.53) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL30565319 | 0.86 | PTPRC (0.53) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL29379298 | 0.82 | PTPRC (0.62) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL826881 | 0.82 | PTPRC (0.62) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL7037796 | 0.80 | PTPRC (0.49) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL20689799 | 0.79 | PTPRC (0.47) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL12778747 | 0.78 | PTPRC (0.50) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL15582381 | 0.77 | PTPRC (0.56) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL20215374 | 0.77 | PTPRC (0.45) | PTPRCPTPN6PTPN11PTPN22CYP2A6 | |
| SCHEMBL13266791 | 0.77 | PTPRC (0.49) | PTPRCPTPN6PTPN11PTPN22CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | AMGEN INC. | 2011-05-19 | — | — | US | disclosed |
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | PTPRC 4192/4885PTPN6 4788/4885PTPN11 4787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.