Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492750 | 0.84 | MAPK1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492721 | 0.74 | MAPK1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492753 | 0.71 | MAPK1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492828 | 0.71 | MAPK1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492764 | 0.71 | MAPK1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492899 | 0.70 | MAPK1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492730 | 0.68 | MAPK1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7955634 | 0.68 | MAPK1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1493069 | 0.68 | MAPK1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492843 | 0.67 | NPC1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |