Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 17/20 | 0.65 |
| ▸ | ACE | P12821 | 8/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919078 | 1.00 | MME (0.65) | MMEACETAAR1MMEL1 | |
| SCHEMBL14890701 | 1.00 | MME (0.65) | MMEACETAAR1MMEL1 | |
| SCHEMBL19177584 | 0.87 | MME (0.59) | MMEACE | |
| SCHEMBL17584940 | 0.87 | MME (0.57) | MMEACETAAR1MMEL1 | |
| Hydrochloric Acid SCHEMBL2705201 | 0.86 | MME (0.62) | MMEACETAAR1MMEL1 | |
| SCHEMBL14890517 | 0.86 | MME (0.53) | MMEACETAAR1MMEL1 | |
| SCHEMBL18597771 | 0.86 | MME (0.53) | MMEACETAAR1MMEL1 | |
| SCHEMBL14919043 | 0.86 | MME (0.53) | MMEACETAAR1MMEL1 | |
| SCHEMBL11918359 | 0.86 | MME (0.67) | MMEACETAAR1MMEL1 | |
| SCHEMBL6903404 | 0.86 | MME (0.67) | MMEACETAAR1MMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964616-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-05-03 | — | — | EP | disclosed |
| EP-2773335-B1 | OXALIC ACID AMIDES AS NEPRILYSIN INHIBITORS, PHARMACEUTICAL COMPOSITION THEREOF AND PREPARATION THEREOF | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-03-08 | — | — | EP | disclosed |
| WO-2013067163-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2013-05-10 | — | — | WO | disclosed |