Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30161006 | 0.76 | KDM4E (0.36) | KDM4EGAA | |
| SCHEMBL27175851 | 0.76 | KDM4E (0.36) | KDM4EGAA | |
| SCHEMBL14932503 | 0.73 | CHEK1 (0.43) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL27581093 | 0.73 | CHEK1 (0.43) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL4413390 | 0.72 | KMT2A (0.41) | ALDH1A1KDM4EGAACYP1A2CYP2C9 | |
| SCHEMBL30428573 | 0.72 | KDM4E (0.45) | ALDH1A1KDM4EGAAPOLB | |
| SCHEMBL17008754 | 0.72 | KDM4E (0.45) | ALDH1A1KDM4EGAAPOLB | |
| SCHEMBL2383543 | 0.72 | KDM4E (0.48) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL29693655 | 0.72 | KDM4E (0.48) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL8139181 | 0.71 | KDM4E (0.42) | ALDH1A1KDM4EGAACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013067142-A1 | COMPOUNDS AND TREATMENT METHODS | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-05-10 | — | — | WO | disclosed |