Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | TEC | P42680 | 1/20 | 0.49 |
| ▸ | TXK | P42681 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | BMX | P51813 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | CD69 | Q07108 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18730592 | 0.91 | BTK (0.49) | BTK | |
| SCHEMBL14915720 | 0.87 | BTK (0.55) | BTKEGFRERBB2TECTXK | |
| SCHEMBL14915718 | 0.87 | BTK (0.55) | BTKEGFRERBB2TECTXK | |
| SCHEMBL20281235 | 0.85 | BTK (0.62) | BTKEGFRERBB2TECTXK | |
| SCHEMBL25707138 | 0.84 | BTK (0.58) | BTKEGFRERBB2TECTXK | |
| SCHEMBL18777835 | 0.83 | BTK (0.55) | BTKEGFRERBB2TECTXK | |
| SCHEMBL14914054 | 0.83 | BTK (0.55) | BTKEGFRERBB2TECTXK | |
| SCHEMBL14916195 | 0.83 | BTK (0.55) | BTKEGFRERBB2TECTXK | |
| SCHEMBL31158074 | 0.83 | BTK (0.55) | BTKEGFRERBB2TECTXK | |
| SCHEMBL14913070 | 0.83 | BTK (0.55) | BTKEGFRERBB2TECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013067274-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | GENENTECH, INC. (US) | 2013-05-10 | — | — | WO | disclosed |