Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 15/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 14/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 14/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 14/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.54 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14934891 | 1.00 | HDAC1 (0.54) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14934718 | 1.00 | HDAC1 (0.54) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14934811 | 0.99 | HDAC1 (0.52) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14918334 | 0.90 | HDAC1 (0.52) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14918820 | 0.90 | HDAC1 (0.52) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14919134 | 0.88 | HDAC1 (0.50) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14918877 | 0.88 | HDAC4 (0.56) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14918761 | 0.88 | HDAC1 (0.47) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14918132 | 0.88 | HDAC1 (0.47) | HDAC1HDAC6HDAC4HDAC3HDAC2 | |
| SCHEMBL14918567 | 0.88 | HDAC4 (0.56) | HDAC1HDAC6HDAC4HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |