Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | NCF1 | P14598 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23412137 | 0.93 | CYP3A4 (0.68) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL23412206 | 0.88 | TDP1 (0.62) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL23412184 | 0.88 | TDP1 (0.62) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL23412382 | 0.88 | TDP1 (0.62) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL23412359 | 0.88 | TDP1 (0.62) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL10090158 | 0.85 | CYP3A4 (0.59) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL9180940 | 0.83 | CYP3A4 (0.60) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL14464160 | 0.83 | CYP3A4 (0.60) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL2025375 | 0.83 | CYP3A4 (0.60) | CYP3A4PDE10AMAPTRAB9ATDP1 | |
| SCHEMBL24272398 | 0.83 | CYP3A4 (0.60) | CYP3A4PDE10AMAPTRAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877752-B2 | 4(1H)-quinolones having antimalarial activity with reduced chemical resistance | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-11-04 | — | — | US | disclosed |
| US-8877752-B2 | 4(1H)-quinolones having antimalarial activity with reduced chemical resistance | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-05-16 | — | — | US | disclosed |
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123258-A1 | 4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance | CDC25C, ABCC1, CDC25A | CYP3A4 46/4885PDE10A 2688/4885MAPT 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.