Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 17/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14938095 | 0.81 | PDE2A (0.43) | PDE2ACYP11B2PDE5APDE7BPDE10A | |
| SCHEMBL14938118 | 0.80 | MAPT (0.37) | PDE2A | |
| SCHEMBL14938305 | 0.79 | PDE2A (0.41) | PDE2ACYP11B2KIF11 | |
| SCHEMBL14996574 | 0.78 | PDE2A (0.48) | PDE2APDE5APDE7BPDE10AKIF11 | |
| SCHEMBL14937981 | 0.76 | PDE2A (0.44) | PDE2APDE5APDE7BPDE10AKIF11 | |
| SCHEMBL14937885 | 0.76 | PDE2A (0.46) | PDE2APDE5APDE7BPDE10A | |
| SCHEMBL14937941 | 0.75 | PDE2A (0.41) | PDE2APDE5APDE7BPDE10AKIF11 | |
| SCHEMBL14938175 | 0.75 | PDE2A (0.43) | PDE2APDE5APDE7BPDE10A | |
| SCHEMBL14938232 | 0.75 | GRM5 (0.43) | PDE2A | |
| SCHEMBL12859335 | 0.75 | PDE2A (0.44) | PDE2APDE5APDE7BPDE10AKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642626-B2 | Ethinyl-pyrazole derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2014-02-04 | — | — | US | disclosed |
| EP-2599775-A1 | ETHINYL-PYRAZOLE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2013-06-05 | — | — | EP | disclosed |
| US-20130123500-A1 | ETHINYL-PYRAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123500-A1 | ETHINYL-PYRAZOLE DERIVATIVE | GABRE, GRIN3A, GRIK5 | PDE2A 2431/4885CYP11B2 164/4885PDE5A 2278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.