Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939389 | 0.93 | NPSR1 (0.61) | NPSR1MAPTSIGMAR1MMP2MMP9 | |
| SCHEMBL14940215 | 0.92 | NPSR1 (0.60) | NPSR1MAPTSIGMAR1MMP2MMP9 | |
| SCHEMBL14939178 | 0.90 | NPSR1 (0.77) | NPSR1MAPTSIGMAR1MMP2MMP9 | |
| SCHEMBL14939441 | 0.89 | NPSR1 (0.72) | NPSR1MAPTSIGMAR1MMP2MMP9 | |
| SCHEMBL14940106 | 0.89 | NPSR1 (0.72) | NPSR1MAPTSIGMAR1MMP2MMP9 | |
| SCHEMBL14939065 | 0.87 | MAPT (0.54) | NPSR1MAPTMMP2MMP9ACHE | |
| SCHEMBL14939405 | 0.87 | NPSR1 (0.59) | NPSR1MAPTSIGMAR1MMP2MMP9 | |
| SCHEMBL14939758 | 0.86 | NPSR1 (0.63) | NPSR1MAPTSIGMAR1MMP2MMP9 | |
| SCHEMBL14939547 | 0.86 | NPSR1 (0.63) | NPSR1MAPTSIGMAR1MMP2MMP9 | |
| SCHEMBL14939721 | 0.86 | NPSR1 (0.52) | NPSR1MAPTSIGMAR1ACHETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |